Blar i forfatter "Bonhoeffer, Sebastian"

Viser treff 1-2 av 2

    • Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiota 

      Tepekule, Burcu; Abel zur Wiesch, Pia; Kouyos, Roger D.; Bonhoeffer, Sebastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-30)
      To understand how antibiotic use affects the risk of a resistant infection, we present a computational model of the population dynamics of gut microbiota including antibiotic resistance-conferring plasmids. We then describe how this model is parameterized based on published microbiota data. Finally, we investigate how treatment history affects the prevalence of resistance among opportunistic ...

    • The Role of Adherence and Retreatment in De Novo Emergence of MDR-TB 

      Cadosch, Dominique; Abel zur Wiesch, Pia; Kouyos, Roger; Bonhoeffer, Sebastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Treatment failure after therapy of pulmonary tuberculosis (TB) infections is an important challenge, especially when it coincides with de novo emergence of multi-drug-resistant TB (MDR-TB). We seek to explore possible causes why MDR-TB has been found to occur much more often in patients with a history of previous treatment. We develop a mathematical model of the replication of Mycobacterium tuberculosis ...